NutriNature™ Expert PDRN Cream
NutriNature™ Expert PDRN Cream
The Korean clinic-grade cream that calms redness after waxing and threading or Plucking — no steroids, no harsh actives. Cellular repair starts from day one with Centella Asiatica + PDRN Complex.
Only 28 tubes left in this small batch
👁 41 women reading this right now
🛒 Maya from Melbourne just bought Buy 3 Get 2 FREE · 2 min ago
🚚 Estimated arrival: 6–8 working days
I have combination skin that flares up the second I try anything with fragrance or actives. I've wasted hundreds on "gentle" creams that still left me red and stinging. The Skin Calm Cream is the first one that's actually done what it says. Within a week the redness across my cheeks was visibly calmer. My skin looks more even-toned and feels properly hydrated without that heavy, suffocating feeling. I don't dread my skincare routine anymore — that's honestly the biggest win.
Every time I get my face threaded, the skin stays red and irritated for days — sometimes a week. I'd been dealing with that for years and just accepted it as normal. A friend with similar skin mentioned this cream, so I gave it a try. I applied it the evening after threading, and honestly, by the next morning, the redness had already calmed down so much. No bumps, no prolonged inflammation. My beautician even asked what I'd changed. I now apply it before and after, and my skin recovers so much faster. Can't imagine going back.
I've had rosacea for about six years, and managing flare-ups is a full-time job. Hot weather, stress, certain foods — it all shows up instantly on my face. I was recommended to look into Centella-based products by my dermatologist, and this one kept coming up. I've now been using it for three weeks, and the baseline redness on my nose and cheeks is genuinely reduced. It doesn't sting, it doesn't clog my pores, and it layers beautifully under SPF. I finally feel like I have something in my routine that's working with my skin rather than against it.
NutriNature™ Expert PDRN Cream
Visibly reduces acne scarring & dark spots caused by hormonal imbalances
Stimulates collagen production for smoother, firmer skin
Accelerates skin cell regeneration — fades hyperpigmentation up to 3x faster
Calms redness and chronic inflammation from hormonal breakouts
Restores skin barrier damaged by PCOS hormonal fluctuations
Lightweight, non-comedogenic — won't clog pores or trigger breakouts
Clinically studied compound — not a trend, not a gimmick
Formulated specifically for sensitive, hormonal skin
Most skincare fails PCOS skin because it treats the surface. Not the source.
- Vitamin C serums — brighten temporarily, but can't repair cellular damage from chronic hormonal inflammation
- Retinol — causes irritation and purging on already reactive hormonal skin
- Laser treatments — Very expensive, multiple sessions, no guarantee for hormonal scarring
- Prescription creams — address one symptom at a time, often with side effects
PDRN is different. It doesn't mask the damage. It signals your skin to repair itself at a cellular level — the way your skin was designed to heal before hormones disrupted the process.
PDRN (Polydeoxyribonucleotide) is a clinically studied compound. When applied to skin:
Step 1 — Activates A2A receptors
Triggers your skin's own regeneration pathway — the same one aesthetic clinics activate with injectable PDRN treatments
Step 2 — Boosts collagen synthesis
Rebuilds the structural foundation broken down by years of hormonal acne and inflammation
Step 3 — Reduces chronic inflammation
Calms the skin at a cellular level — not just on the surface
Step 4 — Accelerates tissue repair
Fades scars, dark spots, and uneven texture faster than your skin can manage alone
Used in aesthetic clinics worldwide in injectable form for over a decade. Now in a topical cream — built for hormonal skin.
Use morning and night:
- Cleanse with a gentle, pH-balanced cleanser
- Apply a pea-sized amount to affected areas
- Massage gently in circular motions until fully absorbed
- Morning only: follow with SPF 30+ (PDRN increases UV sensitivity)
For best results: Use daily for 90 days. Pair with the Cyperus Root Elixir™ for complete PCOS skin and hair support.
Patch test before first use. Avoid the eye area. Keep out of reach of children.
Made for you if:
✓ You have PCOS and deal with hormonal acne, scarring, or dark spots
✓ Your skin texture is uneven, and nothing has worked long-term
✓ You've tried retinol, vitamin C, niacinamide — some help, never enough
✓ Your skin is sensitive, and the strongest treatments make it worse
✓ You want a clinically backed solution — not another empty promise
Not for you if you want overnight results. PDRN works with your skin's biology. Full results take 8–12 weeks of consistent use. That's not a weakness — that's how real repair works.
No. And the difference matters.
Most PDRN products are underdosed, unstable, or use synthetic alternatives that don't replicate clinical results.
NutriNature PDRN Cream is formulated differently:
- Pharmaceutical-grade PDRN — same concentration as clinical aesthetic use
- Stabilised for topical delivery — PDRN degrades with heat; ours is cold-chain preserved and formulated to penetrate skin
- No fillers, no parabens, no synthetic hormones — made for hormonally sensitive skin
- 3rd party tested every batch — purity, potency, zero contaminants
- Dermatologist reviewed for PCOS skin types
Cheap PDRN is everywhere. Effective PDRN is rare.
Key Active:
Polydeoxyribonucleotide (PDRN) — pharmaceutical-grade skin regenerator
Supporting Ingredients:
Niacinamide (5%) — fades dark spots, strengthens skin barrier
Centella Asiatica — anti-inflammatory, collagen support, wound healing
Hyaluronic Acid — deep hydration, smooths and plumps
Allantoin — soothes irritation, promotes gentle cell turnover
Ceramides — restores and locks in skin barrier function
Free from: Parabens · Sulphates · Synthetic fragrances · Synthetic hormones · Heavy metals
"Threaded. Waxed. Plucked. Then Healed."
Real Women. Raw Skin. Real Repair.
"The unfiltered before & after — same skin you've been hiding."
Customer Reviews
Real skin. Real glow. Real PDRN. ★ 4.8/5 from verified buyers
My cystic flare-up calmed in weeks 😭
My PCOS hormonal acne went from angry, red and weeping to THIS. I genuinely didn't leave the house without a full face of makeup. The PDRN and cica calmed the inflammation and my skin started actually healing instead of fighting itself. The before still makes me wince.
12 weeks, 4 photos — my marks faded
I photographed my cheek every few weeks because I didn't believe skincare could do this. The breakouts AND the brown marks they left behind both faded. My skin looks like skin again, not a battlefield. So glad I tracked it.
My post-acne dark marks finally faded 🙌
On deeper skin, the dark spots acne leaves behind stay for MONTHS. I'd resigned myself to "that's just my face now." This faded them and gave me a glow I haven't had since my teens. I can't stop touching my cheeks.
The brown marks acne left behind are gone
My acne calmed down years ago but the rusty-brown marks never left my cheeks. Concealer just sat on top of them. A few months of this and the photos don't lie — even, clear, bright. I'm gobsmacked.
My melasma & sun spots lightened
I'm 52 and the patchy pigmentation across my cheeks made me look tired and blotchy. I expected nothing at my age. The brightness came back, the spots softened, and my fine lines look plumper too. Genuinely didn't think this was possible.
Seven days. I did a double take.
I took a "before" expecting to be disappointed in a month. A week later my cheek had calmed so much I had to compare the photos twice. I'm not saying it's magic — I'm saying my skin has never responded to anything this fast.
My angry red cheeks finally calmed
My skin was perpetually inflamed — red, bumpy, reactive to everything. The cica + PDRN combo soothed it instead of stripping it like every "acne" product I'd tried. Calm, even, and I'm not hiding behind my hair anymore.
Even, glowy skin again ✨
Uneven tone and dark patches on my cheeks made my skin look dull no matter how much I exfoliated (which honestly made it worse). This evened everything out and gave me that lit-from-within look. The after barely needs foundation.
From breakouts to glass skin
Fair skin shows every red bump and mark. I was layering 6 products and still breaking out. This simplified everything and my skin went clear and dewy. People keep asking what filter I use — it's just my face now.
My acne scars look so much softer
Years of cystic acne left my cheeks textured and marked. I'd booked a consult for laser before trying this first. The dents look softer, the marks faded, my skin looks smoother in every light. Cancelled the laser.
My PCOS chin acne — finally calm
The deep painful spots along my jaw and chin flared with my cycle every month. This calmed the redness and helped the marks fade between flares. My skin finally gets a chance to recover instead of constantly being inflamed.
I tracked it week by week — swipe
I'm a serial sceptic so I documented everything. Each photo my cheek got a little clearer and calmer. Seeing it in stages is what made me a believer — this isn't a one-good-lighting fluke, it's consistent.
The rough patch around my chin smoothed out
I had bumpy texture and dark patches around my mouth and chin that no amount of exfoliating fixed (it just made it angrier). This calmed and smoothed it. The skin there finally looks even and soft. So relieved.
The salmon-DNA cream TikTok won't shut up about
I rolled my eyes at "salmon DNA in a tube." Then I read that PDRN is literally used in clinics for skin regeneration. Tried the Madeca PDRN cream and my skin has never been bouncier. The hype is annoyingly real.
My texture is gone — it feels like glass
I used to feel little bumps all over my cheeks under my fingers. I press this in morning and night and now it's smooth. Makeup glides instead of clinging to dry patches. Obsessed isn't a strong enough word.
5 dots, 30 seconds, glowing
Five little dots, pat it in, done. I'm allergic to complicated routines and this is the whole thing. It absorbs instantly, no greasy film, and my skin looks dewy by morning. The easiest skincare win of my life.
TECA + PDRN + B5 — barrier-repair dream
I'd wrecked my barrier over-using actives and my skin stung at everything. Cica (TECA) to soothe, PDRN to regenerate, panthenol to hydrate — it's a thoughtful formula, not a gimmick. My skin stopped reacting within days.
Replaced my entire 7-step routine
My bathroom shelf was a £300 graveyard of serums, essences and ampoules. This one tube does what all of them promised. My skin's clearer and plumper on a fraction of the effort AND the cost. Decluttered and glowing.
Cheaper than La Mer, works harder
I've spent silly money on luxury creams that just felt nice. This one actually DID something — bouncier, brighter, plumper skin in weeks. My wallet and my face are both happier. I'm never going back.
My reactive, rosacea-prone skin had a calm day
My cheeks flush and sting at the slightest thing. I was terrified to try anything new. This is the first cream that didn't set my face on fire — it actually quieted the redness. I almost cried at how soothed my skin felt.
The product shot that made me click "buy"
PDRN, TECA and panthenol with a dermatological heritage — I researched every ingredient before buying because I'm that person. It checks out, and more importantly, my skin checks out: calmer, plumper, glowier. Worth it.
My one complaint: my teenager keeps stealing it
Docking a star purely because my 16-year-old saw my glow and my tube now lives in HER room 🙄. Had to order two. The cream itself? Flawless — my marks faded and my skin's never looked healthier.
My skin stopped feeling tight and tired
My skin was so dehydrated it felt tight by midday and looked crepey. This drenched it with the kind of hydration that lasts. By week two it looked plump and bouncy. I keep catching my reflection and smiling.
Furious I spent £200 on serums first
One star off out of pure spite — I dropped £200 on "miracle" serums before this £-something tube outperformed all of them 😤. My post-acne marks have faded more in 6 weeks than in 2 years. The product's a 10.
My makeup sits SO much better now
Foundation used to cling to every dry, flaky patch and look cakey by lunch. Now my base is smooth and glowy all day because the skin underneath is actually healthy. Half the days I skip foundation entirely.
My retinol's new best friend
Retinol gave me results but left me flaky and raw. Layering this over it stopped the peeling completely and my skin gets all the benefits with none of the irritation. The PDRN repairs while the retinol works. Perfect pairing.
My husband noticed — that NEVER happens
He's never commented on my skin in his life. Last week: "you look really glowy, did you do something?" Reader, I did something. It's this cream. I made him repeat the compliment twice.
The "did you get work done?" cream 😂
Losing a star because people now assume I've had "a little something done" and I have to keep insisting it's a £-something tube of cream 🙄. My skin looks lifted and plump. Annoyingly low-effort, absurdly effective.
My skin barrier finally recovered
Years of acid toners and scrubs left my skin red, stingy and angry. This was like a reset button. The cica calmed it and the PDRN helped it rebuild. My skin feels resilient for the first time in forever.
My pores look tighter and refined
My cheeks were all visible pores and dullness. As my skin got healthier and plumper, the pores look so much smaller and my whole face looks smoother. It's the "skin but better" filter, in real life.
My wedding skin prep — bride glow unlocked 👰
Started this 3 months before my wedding hoping to calm my hormonal breakouts. By the day my skin was so clear and glowy my makeup artist asked what I'd been using. Best pre-wedding decision I made.
Total sceptic. My cheeks proved me wrong.
"Salmon DNA, sure, marketing nonsense." I was ready to return it. Three weeks later my post-acne marks were visibly lighter and I had to eat my words. I owe this little tube an apology.
My skin drama finally stopped
My skin was so dramatic — breaking out, then dry, then red, never settled. This calmed the whole cycle down. It just behaves now. I didn't know what "low-maintenance skin" felt like until this.
Plumped my fine lines like a little iron
The fine lines around my eyes and mouth look genuinely softer and plumper. I'm 47 and this is the first cream that's made a visible difference rather than just feeling expensive. Hydrated, bouncy, glowy.
A little goes a LONG way
I was sure I'd burn through it fast but a pea-sized amount covers my whole face. One tube has lasted ages. Brilliant results AND brilliant value — my skin's clearer and my bank account isn't crying.
My maskne marks finally faded
As a nurse, masks wrecked my cheeks and chin — breakouts and marks that just lingered. This calmed the irritation and faded the marks faster than anything else I tried. My skin can finally breathe and recover.
The dewy look without the grease
Most "glow" creams just make me oily. This sinks in and leaves a healthy dewiness, not a slick. My combination skin loves it — hydrated where it needs it, never greasy. Genuinely impressed.
Stopped hiding behind a full face of makeup
I hadn't left the house barefaced in years because of my marks and redness. Last week I ran errands with just SPF and felt fine. That confidence is worth more than the price ten times over.
Even my dermatologist was curious
At my check-up she said my skin looked the calmest it ever had and asked what I'd added. When I said a PDRN cream she nodded — she knew exactly why it was helping. Reassuring to have her on board.
My sensitive skin tolerates it perfectly
I react to fragrance, essential oils, basically everything. I patch-tested this terrified and… nothing but calm, happy skin. No sting, no flush. For us sensitive types, finding something that just WORKS is everything.
My "tired mum" face is gone
Two kids, no sleep, and my skin showed every minute of it — dull, grey, lifeless. This brought back a glow that makes me look awake even when I'm not. Cheapest "good night's sleep" I've ever bought.
My only problem: I use it everywhere now
Four stars only because it works so well I now slather it on my neck, hands and a scar on my knee, so my tube vanishes faster than it should 😂. My face has never looked better. Reordering on subscription.
It calmed my post-treatment redness
After a facial my skin is usually red and angry for days. Used this and the redness settled overnight. The soothing, repairing feel is unreal — it's now my go-to after any treatment or a bad-skin day.
My skin looks "lit from within"
Not shiny — glowy, from the inside. That healthy, well-rested look I could never fake with highlighter. People keep asking if I'm "doing something different." I am. It's this.
Soothed my eczema-prone patches
The dry, flaky, itchy patches near my nose and brows that flare in winter have calmed right down. The panthenol and cica are so comforting. My skin feels soft and settled instead of tight and irritated.
My maskless glow-up at 3 weeks
I expected to wait months. By week three the difference was obvious — clearer, calmer, brighter. It works faster than anything I've used and I keep recommending it to everyone who'll listen.
Annoyingly, I now preach about it 😂
One star off because I've become unbearable at brunch, forcing my friends to look at my pores. But when your skin clears up after years of struggling, you can't help it. Genuinely life-changing for my confidence.
It survived my PCOS hormonal chaos
My PCOS skin breaks out on schedule every month and the marks pile up. This is the first thing that keeps my skin calmer even during a flare and fades last month's marks while I'm at it. A genuine lifesaver.
My neck and chest thank me too
I started taking it down my neck and chest where I get sun damage and crepiness. Everything looks smoother and more even. It's basically a regeneration treatment for every bit of skin I can reach.
Calmed my winter "sandpaper" cheeks
Every winter my cheeks go rough, red and flaky no matter how much I moisturise. This is the first thing to actually fix the texture and keep it soft. My skin feels comfortable in the cold for once.
My boyfriend stole it and now HE glows
Minus one star because my boyfriend "tried a bit," loved it, and now we're fighting over the tube 😅. Works brilliantly on both of us — calmer, smoother, glowier. Ordering a his-and-hers supply.
The plumpest my skin has ever looked
My skin used to look flat and a bit deflated. This brought back a bounce and plumpness I associate with being a decade younger. The PDRN really does seem to wake the skin up. Hooked for life.
Gentle enough for my teenage daughter
My 15-year-old's hormonal breakouts were destroying her confidence and harsh acne products made it worse. This calmed her skin gently without stripping it. Watching her smile at her reflection again — priceless.
My old acne scars look genuinely softer
The little indented scars from teenage acne have always bugged me. After consistent use they look softer and shallower and my skin's smoother overall. I never thought a cream could touch those. Thrilled.
My skin finally feels comfortable
I didn't realise how much my skin had been quietly uncomfortable — tight, stingy, reactive — until this made it stop. Now it just feels calm and happy all day. That alone is worth every penny.
No more "what's wrong with your face" days
I used to wake up dreading the mirror, never knowing what state my skin would be in. Now it's predictably calm and clear. The mental relief of not stressing about my face every morning is huge.
Absorbs in seconds, no pilling
It sinks in instantly and never pills under my SPF or makeup, which every other "rich" cream did. Lightweight but my skin stays hydrated all day. The texture is perfect — I actually look forward to applying it.
My confidence came back with my skin
Clear skin changed how I show up — I make eye contact, I take the photo, I don't apologise for my face. This cream gave me that back. It's so much more than skincare for me.
Faded my dark spots better than vitamin C
I'd been on vitamin C serums for ages with slow progress. This faded my dark spots faster and without the irritation. My tone is the most even it's been in years. Wish I'd swapped sooner.
My sister with perfect skin asked to borrow it
My sister has always had annoyingly perfect skin and even SHE wanted in after seeing my glow. If it impresses the genetically blessed, you know it's good. We now have a shared standing order 😂.
Day and night, my whole routine now
Cleanse, this, SPF in the morning, this at night. That's it. I cancelled three subscriptions because this one tube replaced all of them. Simpler, cheaper, and my skin looks better than when I did the most.
My rosacea flush has calmed down
The permanent red flush across my cheeks and nose has visibly softened. Heat, wine, stress — they don't set me off the way they did. The cica is clearly doing its job. I feel so much less self-conscious.
It healed my over-exfoliation guilt
I went overboard with acids and gave myself a stinging, peeling mess. This nursed my skin back to health within a couple of weeks. If you've damaged your barrier chasing "glow," this is the reset you need.
My skin looks expensive now 😂
You know that smooth, glowy, "she gets facials" look? I have it now and I just use one tube at home. Clear, even, bouncy. My skin's giving rich-girl energy on a normal-girl budget.
Calmed my "tretinoin uglies"
The flaky, purging, irritated phase of starting tretinoin nearly made me quit. Buffering with this got me through it — no peeling, no rawness. Now I get the tret results with comfortable, happy skin. Essential pairing.
My glow survived a long-haul flight
Flying usually leaves my skin dull, dry and broken out. I slathered this on before a 14-hour flight and landed looking… fine? Better than fine. It's my travel hero now — hydration that actually holds up.
My maskne, marks AND redness — all better
It's rare for one product to tackle several things at once, but this calmed my breakouts, faded the marks AND soothed my redness. My skin looks healthy as a whole, not just "less bad in one area." Genuinely impressed.
If you're hesitating — just try it 💚
I read every review before buying because I'd been let down so many times. So if you're where I was: just try it. Calmer, clearer, glowier skin in weeks. I only wish I'd stopped hesitating and started sooner.